Top 20 publications

  1. MJ Humphries, K Olden and KM Yamada (1986) A synthetic peptide from fibronectin inhibits experimental metastasis of murine melanoma cells. Science 233: 467-470.


  2. MJ Humphries, SK Akiyama, A Komoriya, K Olden and KM Yamada (1986) Identification of an alternatively spliced site in human plasma fibronectin that mediates cell type-specific adhesion. J. Cell Biol. 103: 2637-2647.


  3. MJ Humphries, A Komoriya, SK Akiyama, K Olden and KM Yamada (1987) Identification of two distinct regions of the type III connecting segment of human plasma fibronectin that promote cell type-specific adhesion. J. Biol. Chem. 262: 6886-6892.


  4. MJ Humphries, KM Yamada and K Olden (1988) Investigation of the biological effects of anti-cell adhesive synthetic peptides that inhibit experimental metastasis of B16-F10 murine melanoma cells. J. Clin. Invest. 81: 782-790.


  5. EA Wayner, A Garcia-Pardo, MJ Humphries, JA McDonald and WG Carter (1989) Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin. J. Cell Biol. 109: 1321-1330.


  6. AP Mould, LA Wheldon, A Komoriya, EA Wayner, KM Yamada and MJ Humphries (1990) Affinity chromatographic isolation of the melanoma adhesion receptor for the IIICS region of fibronectin and its identification as the integrin α4β1. J. Biol. Chem. 265: 4020-4024.


  7. AP Mould, A Komoriya, KM Yamada and MJ Humphries (1991) The CS5 peptide is a second site in the IIICS region of fibronectin recognized by the integrin α4β1. Inhibition of α4β1 function by RGD peptide homologues. J. Biol. Chem. 266: 3579-3585.


  8. A Komoriya, LJ Green, M Mervic, SS Yamada, KM Yamada and MJ Humphries (1991) The minimal essential sequence for a major cell-type specific adhesion site (CS1) within the alternatively spliced IIICS domain of fibronectin is Leu-Asp-Val. J. Biol. Chem. 266: 15075-15079.


  9. AP Mould, SK Akiyama and MJ Humphries (1995) Regulation of integrin α5β1-fibronectin interactions by divalent cations: Evidence for distinct classes of binding sites for Mn2+, Mg2+ and Ca2+. J. Biol. Chem. 270: 26270-26277.


  10. AP Mould, SK Akiyama and MJ Humphries (1996) The inhibitory anti-β1 integrin monoclonal antibody 13 recognizes an epitope that is attenuated by ligand occupancy: Evidence for allosteric inhibition of integrin function. J. Biol. Chem. 271: 20365-20374.


  11. AP Mould, JA Askari, S Aota, KM Yamada, A Irie, Y Takada, HJ Mardon and MJ Humphries (1997) Defining the topology of integrin α5β1-fibronectin interactions using inhibitory anti-α5 and anti-β1 monoclonal antibodies: Evidence that the synergy sequence of fibronectin is recognized by the amino-terminal repeats of the α5 subunit. J. Biol. Chem. 272: 17283-17292.


  12. T Ng, D Shima, A Squire, PIH Bastiaens, S Gschmeissner, MJ Humphries and PJ Parker (1999) PKCα regulates β1 integrin-dependent cell motility through association and control of integrin traffic. EMBO J. 18: 3909-3923.


  13. AP Mould, JA Askari and MJ Humphries (2000) Molecular basis of ligand recognition by integrin α5β1. I. Specificity of ligand binding is determined by amino acid sequences in the second and third NH2-terminal repeats of the α subunit. J. Biol. Chem. 275: 20324-20336.


  14. AP Mould, JA Askari, S Barton, AD Kline, PA McEwan, SE Craig and MJ Humphries (2002) Integrin activation involves a conformational change in the α1 helix of the β subunit A-domain. J. Biol. Chem. 277: 19800-19805. Full text | PubMed entry


  15. Z Mostafavi-Pour, JA Askari, SJ Parkinson, PJ Parker, TTC Ng and MJ Humphries (2003) Integrin-specific signaling pathways controlling focal adhesion formation and cell migration. J. Cell Biol. 161: 155-167. Full text | PubMed entry


  16. AP Mould, SJ Barton, JA Askari, PA McEwan, PA Buckley, SE Craig and MJ Humphries (2003) Conformational changes in the integrin βA-domain provide a mechanism for signal transduction via hybrid domain movement. J. Biol. Chem. 278: 17028-17035. Full text | PubMed entry


  17. AP Mould, EJ Symonds, PA Buckley, JG Grossmann, PA McEwan, SJ Barton, JA Askari, SE Craig, J Bella and MJ Humphries (2003) Structure of an integrin-ligand complex deduced from solution x-ray scattering and site-directed mutagenesis. J. Biol. Chem. 278: 39993-9. Full text | PubMed entry


  18. MD Bass, KA Roach, MR Morgan, Z Mostafavi-Pour, T Schoen, T Muramatsu, U Mayer, C Ballestrem, JP Spatz and MJ Humphries (2007) Syndecan-4-dependent Rac1 regulation determines directional migration in response to the extracellular matrix. J. Cell Biol. 177: 527-38. Full text | PubMed entry


  19. MD Bass, MR Morgan, KA Roach, J Settleman, AB Goryachev and MJ Humphries (2008) p190RhoGAP is the convergence point of adhesion signals from α5β1 integrin and syndecan-4. J. Cell Biol. 181: 1013-26. Full text | PubMed entry


  20. JD Humphries*, A Byron*, MD Bass, SE Craig, JW Pinney, D Knight and MJ Humphries (2009) Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6. Sci. Signal. 2: ra51. Full text | Reprint | PubMed entry